“The genes are evolving at a very faster rate and getting mutated to a denatured form”
What is Gene mutation and its effect?
A gene mutation is a change in the DNA sequence of a gene. DNA, or deoxyribonucleic acid, is the genetic material that contains the specific instructions for the overall development and function of the living organisms. A gene is a segment of DNA that encodes the instructions for making a specific protein or RNA molecule which further gives effect to a particular action or output.
There are various causes of the gene mutations that can occur naturally as a result of errors during DNA replication or repair on its own, or they can be caused by so many other factors like exposure to environmental factors such as radiation, chemicals, smoke, viruses or stress (new in trend). Gene mutations can be classified in several ways, including by their effect on the function of the gene or protein, their location within the gene, and their inheritance pattern as in many cases the finding of the inheritance pattern is a challenge without the availability of complete information.
Some gene mutations have no effect on the function of the gene or protein, while others can alter the protein’s structure or function. Depending on the location and nature of the mutation, it can result in a variety of disorders, including genetic diseases, cancer, or developmental disorders.
Some gene mutations have no effect on the function of the gene or protein, while others can alter the protein’s structure or function. Depending on the location and nature of the mutation, it can result in a variety of disorders, including genetic diseases, cancer, or developmental disorders.
Some gene mutations have no effect on the function of the gene or protein, while others can alter the protein’s structure or function. Depending on the location and nature of the mutation, it can result in a variety of disorders, including genetic diseases, cancer, or developmental disorders.
Clinical Trials and need:
Clinical trials are a type of research that studies and verifies new molecules and treatments and evaluates its efficacies on human health outcomes from the most common ailments to the deadly disorders. There could be people from various demographics and other inclusions and exclusions and their condition as healthy and diseased volunteers at their best to take part in clinical trials studies to test medical interventions including drugs, cells, biological products, surgical procedures, implants, artificial life support compact devices, radiological procedures, medical devices, behavioral treatments and preventive care. There are many palliative care centers in India and around the world where the diseased or last phase patients or the one who has lost the hope of getting cured are being accommodated to help them get temporary care while helping them suffer from the diseased condition.
Clinical trials are very carefully and precisely designed, reviewed, carried out and completed, and need to be approved before they can start by various ethical and governing and compliance bodies over the research plan, studies, trials and their possible side effects. Selection of the trial participants are formed from the people of different ages and conditions who can take part in clinical trials, including children.
There are 4 phases of biomedical clinical trials:
Preclinical – process of testing the molecule on animals or equivalent cells of similar genomics as of human or similar to maximum extent.
Phase I studies – process of testing new drugs for the first time in a very small group of people to evaluate the safety level of dosage range and identify any side effects.There are no therapeutic or diagnostic goals set.
Phase II studies – process of testing treatments that have been found to be safe in phase I but now need a larger group of human subjects to monitor for any adverse effects.
Phase III studies – is the main phase and is conducted on a larger population and in different regions and countries with various demographics set..
Phase IV studies – is the process of post marketing surveillance where the events are logged in terms of side effects in the form of AEs and SAEs, so called Pharmacovigilance.
Challenges at Research level and at evolution level:
– The genes are evolving at a very faster rate and getting mutated to a denatured form, than it takes to get the approval on one damn molecule to research and make that as a potent drug in treating a specific condition on living beings.
– It has become a burden on the healthcare side whether to keep researching on every single disorder, condition or disease at a molecular level, patient tailored treatments etc. It’s become a complete chaos of so many fucking molecules vs chemicals in day to day life.
– There is a big leap and competition in making the availability of the chemicals and molecule extracts to the population for consumption with no further follow ups or outputs.
– The extent of ease and the pace at which Biotechnology has helped us in deriving the solution for a better move, but somehow the move has taken faster towards the negative side with agility.
– Sooner there will be an option of having a capsule of extracts instead of a meal to survive.
– The exhaustion of the scope can be seen at the research side, where the research is going on since long to find the cure for a particular mutation but the same has evolved to a different state which is far more expressive and agile in continuously evolving to a new strain.
– Experts have become so baffled with respect to the available option of treatment against the no of disorders that the perfect selection or the proposal of the treatment plan has become a dare act.
There is a need of finding the gaps in the user behavior, patterns, practices, catalyzer, pace etc. to nail down the ailments at its bud. This may need a huge change in certain laws, audits, guidelines and the effectiveness of their implementation and controls.
